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KMID : 0882420080740000233
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Korean Journal of Medicine
2008 Volume.74 No. 0 p.233 ~ p.238
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Microscopic polyangiitis presenting as peripheral neuropathy
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Hong Sung-Guon
Kang Hyo-Jong
Yoon Jae-Young
Park Ju-Ie
Min Sung-Yang
Paik So-Ya
Yu Hyun-Jeung
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Abstract
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Microscopic polyangiitis (MPA) is a systemic small vessel (arteriole, venule, capillary) vasculitis with few or no immune deposits and no granulomatous inflammation. It may be difficult to differentiate between PAN (polyarteritis nodosa) and MPA simply based on clinical data. However, the presence or absence of antineutrophil cytoplasmic antibody (ANCA), findings on visceral angiography, and biopsy from involved organs are helpful adjuncts toward diagnosing MPA or PAN. Peripheral neuropathy may be the initial manifestation of MPA, and it occurs in approximately 20～30% of patients with MPA. We report the case of a 65-year-old woman who presented with paresthesias and motor weakness of the extremities and who was later diagnosed with MPA based on the findings of positive P-ANCA and negative angiography, along with findings on sural nerve biopsy. We did not find any evidence of kidney or lung involvement. We followed the patient for over two years, and her course was benign after initiation of immune-modulating therapy. (Korean J Med 74:S233-S238, 2008)
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KEYWORD
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Microscopic polyangiitis, Polyarteritis nodosa, Peripheral neuropathy
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